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The aging male: impact of aging on male reproduction | Biogerontology | Springer Nature Link
We propose two complementary explanations for this unexpected finding – multinutrient supplementation contributed to: (1) a reduced need for anti-inflammatory signaling (i.e., counter-regulation), as inflammation resolved, and/or (2) an upstream reduction of immune activation that reduced the production of both pro- and anti-inflammatory factors, as discussed below
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In fact, PE and ED are closely interconnected, potentially creating a vicious cycle in which either sexual dysfunction could be a risk factor for the development of the other [194] or for the progression from subclinical to more severe forms [15,27]